Protein-Protein Interference Blockade
Protein-protein interactions are universal to life. They occur as part of normal physiological processes at the cellular level. However, many human diseases are known to be caused by abnormal protein-protein interactions such as cancer, neurodegenerative disorders, cardiovascular and infectious diseases.
In the past, targeting intracellular protein-protein interaction sites as potential targets for drugs has been challenging because the binding sites are non-distinct; they are flat, featureless and relatively large.
With recent advances in protein-protein focused drug discovery technologies, these challenges have been overcome. Today, protein-protein interaction modulators are an attractive emerging class of molecular targets. Several modulator therapeutics are on the market, and many more are advancing through clinical studies.
Our approach is to leverage the advantages of peptide arrays to precisely
identify and target the contact points of two interacting proteins. We then link
specific membrane-permeable sequences to selected peptide candidates to allow
penetration through the blood-brain barrier and/or the plasma membrane of cells.
Achieving both blood brain-barrier penetration and cell permeability are
significant advantages of our technology, which broadens the opportunity to
develop new targeted therapies for a variety of diseases. The ability to cross
the blood-brain barrier is especially vital for CNS disorders, where the
therapeutic target resides in the brain.
We have validated our protein interference blockade technology in vitro and in vivo involving multiple protein targets in cardiovascular and neurological indications.
Our protein-protein interference blockade platform offers several significant advantages compared to small molecules and antibodies.
|Characteristics||Interference Peptide||Small Molecule Inhibitor||Antibody|
|Ease of manufacturing||✓||MAYBE||X|
|Ease of finding a new molecule||✓||X||MAYBE|
|Blood-brain barrier and cell permeability||✓||MAYBE||X|
|Does not require information on protein structure||✓||X||MAYBE|
|Can target disorderly parts of a target protein||✓||X||MAYBE|